{"id":1632,"date":"2023-10-21T10:22:14","date_gmt":"2023-10-21T09:22:14","guid":{"rendered":"https:\/\/directpharmacyuk.com\/?post_type=product&p=1632"},"modified":"2025-05-13T03:39:11","modified_gmt":"2025-05-13T02:39:11","slug":"cyclizine-hydrochloride","status":"publish","type":"product","link":"https:\/\/directpharmacyuk.com\/index.php\/product\/cyclizine-hydrochloride\/","title":{"rendered":"Cyclizine"},"content":{"rendered":"

Cyclizine hydrochloride<\/strong><\/h1>\n

Cyclizine hydrochloride is a piperazine-derivative antihistamine used as an antivertigo\/antiemetic agent. Cyclizine is used in the prevention and treatment of nausea, vomiting<\/a>, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. Although the mechanism by which cyclizine exerts its antiemetic and antivertigo effects has not been fully elucidated, its central anticholinergic properties are partially responsible. The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. It also possesses anticholinergic, antihistaminic, central nervous system depressant, and local anesthetic effects.<\/p>\n

Mechanism of action<\/p>\n

Vomiting (emesis) is essentially a protective mechanism<\/a> for removing irritant or otherwise harmful substances from the upper GI tract. Emesis or vomiting is controlled by the vomiting centre in the medulla region of the brain, an important part of which is the chemotrigger zone (CTZ). The vomiting centre possesses neurons which are rich in muscarinic cholinergic and histamine containing synapses. These types of neurons are especially involved in transmission from the vestibular apparatus to the vomiting centre. Motion sickness principally involves overstimulation of these pathways due to various sensory stimuli. Hence the action of cyclizine which acts to block the histamine receptors in the vomiting centre and thus reduce activity along these pathways. Furthermore<\/a> since cyclizine possesses anti-cholinergic properties as well, the muscarinic receptors are similarly blocked.<\/p>\n

cyclizine hydrochloride dosing information<\/h2>\n

Usual Pediatric Dose for Motion Sickness:<\/b><\/p>\n

6 years and older: 25 mg orally every 6 to 8 hours
\n-Maximum dose: 75 mg\/day<\/p>\n

Comments:
\n-For the prevention of travel sickness, patients should take the first dose approximately 1 hour prior to departure or at the onset of symptoms.
\n-Patients should be cautioned to avoid driving or operating machinery while taking this drug.<\/p>\n","protected":false},"excerpt":{"rendered":"

Cyclizine hydrochloride Cyclizine hydrochloride is a piperazine-derivative antihistamine used as an antivertigo\/antiemetic agent. Cyclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. Although the mechanism by which cyclizine exerts its antiemetic […]<\/p>\n","protected":false},"featured_media":1633,"comment_status":"open","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"product_brand":[],"product_cat":[514],"product_tag":[708,700,705,701,699,707,703,706,702,704],"class_list":{"0":"post-1632","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-antihistamines","7":"product_tag-bnf-cyclizine","8":"product_tag-cyclizine","9":"product_tag-cyclizine-50mg","10":"product_tag-cyclizine-bnf","11":"product_tag-cyclizine-hydrochloride","12":"product_tag-cyclizine-hydrochloride-50mg","13":"product_tag-cyclizine-in-pregnancy","14":"product_tag-cyclizine-pregnancy","15":"product_tag-cyclizine-side-effects","16":"product_tag-cyclizine-tablets","18":"first","19":"instock","20":"sale","21":"shipping-taxable","22":"purchasable","23":"product-type-simple"},"yoast_head":"\nCyclizine hydrochloride | directpharmacyuk.com<\/title>\n<meta name=\"description\" content=\"Cyclizine hydrochloride is a piperazine-derivative antihistamine used as an antivertigo\/antiemetic agent. 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